α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Base Information

Chemical Name:α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate
CAS No.:96195-10-7
Molecular Formula:C₃₁H₃₆N₂O₆
Molecular Weight:532.637
Hs Code.:

α-benzhydryl O-benzyl-N<sup>α</sup>-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Synonyms:α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

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Chemical Property of α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

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Technology Process of α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

There total 3 articles about α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 622-33-3
N-benzyloxyamine

: 71264-14-7
N^α-(tert-butyloxycarbonyl)-L-α-aminoadipic acid α-benzhydryl ester

: 96195-10-7
α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; 1.) 0 deg C, 3 h, 2.) RT, overnight;
DOI:10.1021/jo00213a013

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 96195-10-7
α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / dimethylformamide; H₂O / 2 h / Ambient temperature

2: 72 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / tetrahydrofuran; H₂O / 1.) 0 deg C, 3 h, 2.) RT, overnight

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00213a013

Reference yield:

: 71264-13-6
α-L-aminoadipic acid α-benzhydryl ester

: 96195-10-7
α-benzhydryl O-benzyl-N^α-(tert-butyloxycarbonyl)-L-α-aminoadipo-δ-hydroxamate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / dimethylformamide; H₂O / 2 h / Ambient temperature

2: 72 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / tetrahydrofuran; H₂O / 1.) 0 deg C, 3 h, 2.) RT, overnight

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00213a013