4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

Base Information

Chemical Name:4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide
CAS No.:1269420-51-0
Molecular Formula:C₁₉H₁₇ClN₆O₃S
Molecular Weight:444.901
Hs Code.:

Synonyms:4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

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Chemical Property of 4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

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Technology Process of 4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

There total 4 articles about 4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86225-73-2
3-chloro-2,6-difluorobenzonitrile

: 1269420-51-0
4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / isopropyl alcohol / 2 h / 80 °C / Sealed vial

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 1.5 h / 40 °C / Cooling with water bath

2.2: 20 - 120 °C / Sealed vial

3.1: chloroform / 55 °C / Sealed vial

4.1: ammonia / methanol / 2.5 h / 40 °C / Sealed vial

With ammonium hydroxide; ammonia; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; chloroform; isopropyl alcohol;

Reference yield:

: C₁₉H₁₅Cl₂N₅O₃S

: 1269420-51-0
4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: With ammonia; In methanol; at 40 ℃; for 2.5h; Sealed vial;

Reference yield:

: 2-amino-3-chloro-6-fluorobenzonitrile

: 1269420-51-0
4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 1.5 h / 40 °C / Cooling with water bath

1.2: 20 - 120 °C / Sealed vial

2.1: chloroform / 55 °C / Sealed vial

3.1: ammonia / methanol / 2.5 h / 40 °C / Sealed vial

With ammonia; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; chloroform;