86225-73-2

Basic information

• Product Name: 3-CHLORO-2,6-DIFLUOROBENZONITRILE
• Synonyms: 3-CHLORO-2,6-DIFLUOROBENZONITRILE
• CAS NO: 86225-73-2
• Molecular Formula: C₇H₂ClF₂N
• Molecular Weight: 173.55
• Mol File: 86225-73-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 198 °C at 760 mmHg
• Flash Point: 73.6 °C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 0.367mmHg at 25°C
• Refractive Index: 1.5125
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Not miscible or difficult to mix with water.
• CAS DataBase Reference: 3-CHLORO-2,6-DIFLUOROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2,6-DIFLUOROBENZONITRILE(86225-73-2)
• EPA Substance Registry System: 3-CHLORO-2,6-DIFLUOROBENZONITRILE(86225-73-2)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 86225-73-2(Hazardous Substances Data)

Usage

Uses

3-Chloro-2,6-difluorobenzonitrile is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H2ClF2N/c8-5-1-2-6(9)4(3-11)7(5)10/h1-2H

Upstream product

• 190011-87-1 1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde 
• 4681-11-2 2,5,6-tri-chloro-benzonitrile 

Downstream Products

• 1396310-70-5 N-(4-chloro-2-cyano-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yloxy)phenyl)propane-1-sulfonamide 
• 1396311-82-2 3-chloro-6-fluoro-2-(3-methyl-4-oxo-quinazolin-6-yl)oxy-benzonitrile 
• 1269420-51-0 4-amino-quinazoline-8-carboxylic acid [6-chloro-2-cyano-3-(propane-1-sulfonylamino)-phenyl]-amide 
• 1269421-40-0 N-(3-amino-4-chloro-2-cyanophenyl)propane-1-sulfonamide 
• 1897-52-5 2,6 difluorobenzonitrile 

Relevant articles and documents

Pharmaceutically active compounds

Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group --(CH2)c NHCO2 R10, a group --(CH2)c NR5 R6, or a group --CO2 R11 ; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group --NHCO2 R10 ; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)a Z(CH2)b ; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.