2-(4-ethoxyphenyl)acetyl chloride

Base Information

• Chemical Name: 2-(4-ethoxyphenyl)acetyl chloride
• CAS No.: 10368-35-1
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 10368-35-1.mol

Synonyms:4-ethoxyphenylacetic acid chloride

Chemical Property of 2-(4-ethoxyphenyl)acetyl chloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Ethoxyphenyl)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-ethoxyphenyl)acetyl chloride

There total 4 articles about 2-(4-ethoxyphenyl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-ethoxyphenylacetic acid (4919-33-9) → 4-ethoxyphenylacetic acid chloride (10368-35-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Reflux;

Reference yield:

4-ethoxyphenylacetic acid methyl ester (29056-03-9) → 4-ethoxyphenylacetic acid chloride (10368-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; methanol / 3 h / 20 °C

2: thionyl chloride / chloroform; N,N-dimethyl-formamide / 75 °C / Inert atmosphere

With methanol; thionyl chloride; sodium hydroxide; In chloroform; N,N-dimethyl-formamide;

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 4-ethoxyphenylacetic acid chloride (10368-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 65 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: sodium hydroxide; methanol / 3 h / 20 °C

3.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 75 °C / Inert atmosphere

With methanol; thionyl chloride; potassium carbonate; sodium hydroxide; In chloroform; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4-ethoxyphenylacetic acid

4-ethoxyphenylacetic acid methyl ester

Methyl 4-hydroxyphenylacetate

Downstream raw materials:

2-(4-ethoxy-phenyl)-1-[2]thienyl-ethanone

4,4'-diethoxy-deoxybenzoin

2-(4-ethoxyphenyl)-N-(4-methylbenzyl)-N-(1-methylpiperidin-4-yl)acetamide hydrochloride

Refernces

• 1、 -. "C1 substituted 3, 4 - ISO-quinoline alkaloids of the preparation and its medicinal use". Paragraph 0066; 0076; 0077. . Retrieved 2019/03/28.
• 2、 -. "9 - Substituted derivative of berberine at the preparation and its use in medicine (by machine translation)". Paragraph 0034; 0042; 0043. . Retrieved 2018/04/03.