4-Ethoxyphenylacetic acid

Base Information

• Chemical Name: 4-Ethoxyphenylacetic acid
• CAS No.: 4919-33-9
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 29189900
• European Community (EC) Number: 225-545-3
• DSSTox Substance ID: DTXSID6063648
• Nikkaji Number: J5.200K
• Wikidata: Q27467750
• Mol file: 4919-33-9.mol

Synonyms:4-ethoxyphenylacetic acid;pinstatic acid

Chemical Property of 4-Ethoxyphenylacetic acid

Chemical Property:

• Appearance/Colour: white to beige crystalline powder
• Vapor Pressure: 0.000151mmHg at 25°C
• Melting Point: 87-90 °C
• Refractive Index: 1.5430 (estimate)
• Boiling Point: 318.5 °C at 760 mmHg
• PKA: 4.46±0.10(Predicted)
• Flash Point: 125.8 °C
• PSA: 46.53000
• Density: 1.144 g/cm³
• LogP: 1.71240
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxyphenylaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)CC(=O)O

Technology Process of 4-Ethoxyphenylacetic acid

There total 15 articles about 4-Ethoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

4-ethoxyphenylacetic acid methyl ester (29056-03-9) → 4-ethoxyphenylacetic acid (4919-33-9)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 3h;

Reference yield: 93.0%

ethyl 4-ethoxyphenylacetate (40784-88-1) → 4-ethoxyphenylacetic acid (4919-33-9)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 2h; pH=10 - 14;

Reference yield:

diethyl sulfate (64-67-5) + 4-hydroxyphenylacetate (156-38-7) → 4-ethoxyphenylacetic acid (4919-33-9)

Guidance literature:

diethyl sulfate; 4-hydroxyphenylacetate; With sodium hydroxide; In methanol; water; at 20 ℃;

With hydrogenchloride; In methanol; water; pH=2 - 3;

upstream raw materials:

diethyl sulfate

4-cyanomethylphenol

4-hydroxyphenylacetate

4-[(4-ethoxy-phenyl)-thioacetyl]-morpholine

Downstream raw materials:

4'-ethoxy-deoxybenzoin

4-ethoxyphenylacetic acid chloride

2-(4-ethoxy-phenyl)-1,1-diphenyl-ethanol

2-(4-ethoxy-phenyl)-1-(4-methoxy-phenyl)-1-phenyl-ethanol