3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Base Information

Chemical Name:3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS No.:1429171-31-2
Molecular Formula:C₁₅H₁₂FN₃O₃
Molecular Weight:301.277
Hs Code.:

Synonyms:3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Suppliers and Price of 3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

There total 1 articles about 3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 405-05-0
3-fluoro-4-hydroxybenzaldehyde

: 127-17-3
2-oxo-propionic acid

: 1904-24-1
5-ethyl-2H-pyrazol-3-ylamine

: 1429171-31-2
3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Guidance literature:: With acetic acid; for 2h; Reflux; Inert atmosphere;

Reference yield: 66.0%

: 1429171-31-2
3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1429171-59-4
4-[3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 1429171-31-2
3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: [3-ethyl-6-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperazin-1-ylmethanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl acetamide / 20 °C / Inert atmosphere

2: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 4 h / Heating

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; isopropyl alcohol;