(R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester

Base Information

• Chemical Name: (R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester
• CAS No.: 848865-00-9
• Molecular Formula: C₁₉H₂₂ClFN₂O₇S
• Molecular Weight: 476.91

Synonyms:(R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester

Chemical Property of (R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester

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Technology Process of (R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester

There total 1 articles about (R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

carbonochloridic acid, chloromethyl ester (22128-62-7) + (S)-(-)-N-[[3-[3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxaolidinyl]methyl]acetamide S,S-dioxide (188974-61-0) → (R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester (848865-00-9)

Guidance literature:

(S)-(-)-N-[[3-[3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxaolidinyl]methyl]acetamide S,S-dioxide; With lithium tert-butoxide; In hexane; dichloromethane; acetonitrile; at 0 - 20 ℃; for 0.583333h;

carbonochloridic acid, chloromethyl ester; at 0 - 20 ℃; for 0.166667h;

Reference yield: 74.0%

(R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester (848865-00-9) + Boc-glycine cesium salt (42538-64-7) → (R)-tert-butoxycarbonylamino-acetic acid (acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamoyloxy)-methyl ester

Guidance literature:

With sodium iodide; In acetonitrile; at 82 ℃; Heating / reflux;

Reference yield: 72.0%

(R)-acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid chloromethyl ester (848865-00-9) + N-tert-butoxycarbonyl-isonipecotic acid cesium salt (848865-23-6) → (R)-piperidine-1,4-dicarboxylic acid 4-[(acetyl-{3-[4-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamoyloxy)-methyl] ester 1-tert-butyl ester

Guidance literature:

With sodium iodide; In acetonitrile; Heating / reflux;

upstream raw materials:

carbonochloridic acid, chloromethyl ester

(S)-(-)-N-[[3-[3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxaolidinyl]methyl]acetamide S,S-dioxide

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