Technology Process of (S)-1-(4-(1-(2-(3-(allyloxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione
There total 12 articles about (S)-1-(4-(1-(2-(3-(allyloxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II);
In
1,4-dioxane;
at 80 ℃;
DOI:10.1021/jm3004174
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methylamine / methanol / 1 h / 20 °C
2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C
With
chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); methylamine;
In
1,4-dioxane; methanol;
DOI:10.1021/jm3004174
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrahydrofuran; diethyl ether / 3.16 h / 0 - 20 °C
2.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C
2.2: 12 h / 0 - 20 °C
3.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C
4.1: triethylamine / dichloromethane / 2 h / 20 °C
5.1: acetic acid; trifluoroacetic acid / water / 3 h / 50 °C
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / ethanol; toluene / 20 °C
7.1: sodium hydroxide / methanol; water / 50 °C
8.1: methanesulfonyl chloride; triethylamine / dichloromethane / 20 °C
8.2: 90 °C
9.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C
With
chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); di-isopropyl azodicarboxylate; AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; acetic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;
2.2: Wittig reaction / 6.1: Mitsunobu reaction;
DOI:10.1021/jm3004174
