Technology Process of (S)-2-(3-(allyloxy)phenyl)-1-azidobutan-2-ol
There total 8 articles about (S)-2-(3-(allyloxy)phenyl)-1-azidobutan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2-(3-(allyloxy)phenyl)butane-1,2-diol;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 20 ℃;
With
sodium azide;
In
dichloromethane; N,N-dimethyl-formamide;
at 90 ℃;
DOI:10.1021/jm3004174
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydroxide / ethanol; water / 4 h / 60 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C
3.1: tetrahydrofuran; diethyl ether / 3.16 h / 0 - 20 °C
4.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C
4.2: 12 h / 0 - 20 °C
5.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C
6.1: triethylamine / dichloromethane / 2 h / 20 °C
7.1: acetic acid; trifluoroacetic acid / water / 3 h / 50 °C
8.1: di-isopropyl azodicarboxylate; triphenylphosphine / ethanol; toluene / 20 °C
9.1: sodium hydroxide / methanol; water / 50 °C
10.1: methanesulfonyl chloride; triethylamine / dichloromethane / 20 °C
10.2: 90 °C
With
di-isopropyl azodicarboxylate; AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; benzotriazol-1-ol; acetic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
4.2: Wittig reaction / 8.1: Mitsunobu reaction;
DOI:10.1021/jm3004174
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C
1.2: 12 h / 0 - 20 °C
2.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C
3.1: triethylamine / dichloromethane / 2 h / 20 °C
4.1: acetic acid; trifluoroacetic acid / water / 3 h / 50 °C
5.1: di-isopropyl azodicarboxylate; triphenylphosphine / ethanol; toluene / 20 °C
6.1: sodium hydroxide / methanol; water / 50 °C
7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 20 °C
7.2: 90 °C
With
di-isopropyl azodicarboxylate; AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; acetic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;
1.2: Wittig reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/jm3004174
