2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt
CAS No.:1415312-02-5
Molecular Formula:C₂HF₃O₂*C₂₃H₁₉ClN₂O₅
Molecular Weight:552.891
Hs Code.:

Synonyms:2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

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Chemical Property of 2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

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Technology Process of 2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

There total 3 articles about 2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956229-69-9
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid tert-butyl ester

: 1429316-51-7
C₁₈H₁₈BrClN₂O₃

: 76-05-1
trifluoroacetic acid

: 1415312-02-5
2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

Guidance literature:: 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid tert-butyl ester; C₁₈H₁₈BrClN₂O₃; With potassium carbonate; SilicaCat DPP-Pd; In ethanol; water; at 100 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 2h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 268734-28-7,270596-36-6
(R)-3-Amino-4-(2-chloro-phenyl)-butyric acid

: 1415312-02-5
2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: potassium carbonate / SilicaCat_.(R). DPP-Pd / ethanol; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

3.2: 2 h / 40 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; SilicaCat DPP-Pd; In ethanol; dichloromethane; water;

Reference yield:

: 752963-23-8
(R)-3-amino-4-(2-chloro-phenyl)-butyric acid ethyl ester

: 1415312-02-5
2-{2-[(R)-1-carboxymethyl-2-(2-chlorophenyl)ethylcarbamoyl]pyridin-4-yl}benzoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: potassium carbonate / SilicaCat_.(R). DPP-Pd / ethanol; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

2.2: 2 h / 40 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; SilicaCat DPP-Pd; In ethanol; dichloromethane; water;