-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

Base Information

Chemical Name:-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid
CAS No.:153566-69-9
Molecular Formula:C₁₆H₂₃NO₂
Molecular Weight:261.364
Hs Code.:

<S-(R*,S*)>-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

Synonyms:-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

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Chemical Property of -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

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Technology Process of -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

There total 1 articles about -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 153566-67-7
ethyl -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetate

: 153566-69-9
-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

Guidance literature:: With sodium hydroxide; In methanol; for 18h; Heating;
DOI:10.1021/jm00032a005

Reference yield:

: 153566-69-9
-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

: 7-[(R)-3-(1-Amino-1-methyl-ethyl)-pyrrolidin-1-yl]-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 3A molecular sieves, Et₃N, 2.) diphenyl phosphorazidate / 1.) 1 h, 2.) reflux, 30 h

2: 90 percent / H₂ / 20percent Pd/C / methanol / 14 h / 2585.7 Torr

3: Et₃N / acetonitrile / 18 h / Heating

4: HCl (g) / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; 3 A molecular sieve; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00032a005

Reference yield:

: 153566-69-9
-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

: 143158-54-7
(R)-7-[3-(1-t-butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 3A molecular sieves, Et₃N, 2.) diphenyl phosphorazidate / 1.) 1 h, 2.) reflux, 30 h

2: 90 percent / H₂ / 20percent Pd/C / methanol / 14 h / 2585.7 Torr

3: Et₃N / acetonitrile / 18 h / Heating

With 3 A molecular sieve; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00032a005