3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-7-[3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1- methylethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-, (R)-

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-7-[3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1- methylethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-, (R)-
• CAS No.: 139230-27-6
• Molecular Formula: C25H31ClFN3O5

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-7-[3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1- methylethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-7-[3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1- methylethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-, (R)-

There total 8 articles about 3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-7-[3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1- methylethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-(1'-methyl-1'-t-butoxycarbonylaminoethyl)pyrrolidine + 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (101987-89-7) → (R)-7-3-(1-Amino-1-methylethyl)-1-pyrrolidinyl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride + (R)-7-[3-(1-t-Butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (139230-27-6)

Guidance literature:

With triethylamine; In acetonitrile;

Reference yield:

(3R)-(1'-methyl-1'-t-butoxycarbonylaminoethyl)pyrrolidine + 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (101987-89-7) → (R)-7-[3-(1-t-Butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (139230-27-6)

Guidance literature:

With triethylamine; In acetonitrile;

Reference yield:

(3R)-(1'-Methyl-1'-t-butoxycarbonylaminoethyl)-pyrrolidine + 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (101987-89-7) → (R)-7-[3-(1-Amino-1-methylethyl)-1-pyrrolidinyl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride + (R)-7-[3-(1-t-Butoxycarbonylamino-1-methylethyl)-1-pyrrolidinyl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (139230-27-6)

Guidance literature:

With triethylamine; In acetonitrile;

upstream raw materials:

8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

1,1-dimethylethyl (R)-<1-methyl-1-(3-pyrrolidinyl)ethyl>carbamate

-α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetic acid

ethyl -α,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidineacetate

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