Technology Process of (2S,3R)-methyl 3-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-2,3-dihydroxypropanoate
There total 6 articles about (2S,3R)-methyl 3-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-2,3-dihydroxypropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroquinidine 1 4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III);
In
tert-butyl alcohol;
at 0 - 20 ℃;
stereoselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201101978
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 20 °C / Inert atmosphere
2: hydroquinidine 1 4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III) / tert-butyl alcohol / 0 - 20 °C / Inert atmosphere
With
hydroquinidine 1 4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III);
In
dichloromethane; tert-butyl alcohol;
1: Wittig reaction / 2: Sharpless dihydroxylation;
DOI:10.1002/chem.201101978
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with water bath
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -90 - -80 °C / Inert atmosphere
2.2: 0.5 h / -100 - -10 °C / Inert atmosphere
3.1: dichloromethane / 20 °C / Inert atmosphere
4.1: hydroquinidine 1 4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III) / tert-butyl alcohol / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; hydroquinidine 1 4-phthalazinediyl diether; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; water; potassium carbonate; potassium hexacyanoferrate(III);
In
tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol;
2.2: Wittig reaction / 3.1: Wittig reaction / 4.1: Sharpless dihydroxylation;
DOI:10.1002/chem.201101978
