(S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid

Base Information

• Chemical Name: (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid
• CAS No.: 1392592-61-8
• Molecular Formula: C₈H₁₁N*C₂₅H₂₉NO₄S
• Molecular Weight: 560.758
• Mol file: 1392592-61-8.mol

Synonyms:(S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid

Chemical Property of (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid

There total 3 articles about (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate (222555-06-8) → (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid (1392592-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / cyclohexane / 0.5 h / 45 - 55 °C / Inert atmosphere

1.2: 36 h / 75 - 85 °C

2.1: sodium hydroxide; water / ethanol / 3 h / Inert atmosphere

2.2: 4.5 h / 0 - 45 °C / Inert atmosphere

With water; potassium carbonate; sodium hydroxide; In ethanol; cyclohexane;

Reference yield:

(S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid ethyl ester + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid (1392592-61-8)

Guidance literature:

(S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid ethyl ester; With water; sodium hydroxide; In ethanol; for 3h; Inert atmosphere;

(S)-1-phenyl-ethylamine; In water; at 0 - 45 ℃; for 4.5h; Inert atmosphere;

Reference yield:

methanesulfonic acid 2-[2-methyl-5-(4-methylsulfanyl-phenyl)-pyrrol-1-yl]-ethyl ester (494850-87-2) → (S)-(-)α-1-phenylethylamine salt of (S)-α-ethoxy-4-[2-[-methyl-5-[4-(methylthio) phenyl]-1H-pyrrol-1-yl]ethoxy]benzene-propanoic acid (1392592-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / cyclohexane / 0.5 h / 45 - 55 °C / Inert atmosphere

1.2: 36 h / 75 - 85 °C

2.1: sodium hydroxide; water / ethanol / 3 h / Inert atmosphere

2.2: 4.5 h / 0 - 45 °C / Inert atmosphere

With water; potassium carbonate; sodium hydroxide; In ethanol; cyclohexane;

upstream raw materials:

(S)-1-phenyl-ethylamine

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

methanesulfonic acid 2-[2-methyl-5-(4-methylsulfanyl-phenyl)-pyrrol-1-yl]-ethyl ester

Refernces

• 1、 -. "POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF". Page/Page column 27. . Retrieved 2015/03/16.