(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Base Information

Chemical Name:(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid
CAS No.:1384982-43-7
Molecular Formula:C₃₁H₃₂Cl₂N₂O₇
Molecular Weight:615.51
Hs Code.:

Synonyms:(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Suppliers and Price of (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

There total 16 articles about (E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

: C₃₅H₄₀Cl₂N₂O₇

: 1384982-43-7
(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h; Darkness;
DOI:10.1039/c2ob25701g

Reference yield:

: 1261777-72-3
2-(bromomethyl)-4-iodo-1-nitrobenzene

: 1384982-43-7
(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: water; sodium carbonate / acetone / 48 h / Reflux

2: palladium diacetate / triethanolamine; N,N-dimethyl-formamide / 12 h / 110 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

4: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

5: potassium carbonate / acetonitrile / 24 h / 20 °C / Darkness

6: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

With dmap; water; palladium diacetate; sodium carbonate; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In triethanolamine; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 2: Heck reaction;
DOI:10.1039/c2ob25701g

Reference yield:

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

: 1384982-43-7
(E)-2-(4-(3-(((4-(4-(bis(2-chloroethyl)amino)phenyl)butanoyl)oxy)methyl)-4-nitrostyryl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

2: potassium carbonate / acetonitrile / 24 h / 20 °C / Darkness

3: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/c2ob25701g