(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Chemical Name:(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate
CAS No.:1384982-50-6
Molecular Formula:C₃₄H₃₈Cl₂N₂O₆
Molecular Weight:641.592
Hs Code.:

Synonyms:(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Chemical Property of (E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Technology Process of (E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

There total 13 articles about (E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

: 1384982-49-3
(E)-(2-nitro-5-(4-((tetrahydro-2H-pyran-2-l)oxy)styryl)phenyl)methanol

: 305-03-3
chlorambucil

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h; Darkness;
DOI:10.1039/c2ob25701g

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 0.5 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 20 °C / Inert atmosphere

3: palladium diacetate / triethanolamine; N,N-dimethyl-formamide / 12 h / 110 °C / Inert atmosphere

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

With dmap; potassium tert-butylate; palladium diacetate; pyridinium p-toluenesulfonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; triethanolamine; dichloromethane; N,N-dimethyl-formamide; 2: Wittig reaction / 3: Heck reaction;
DOI:10.1039/c2ob25701g

Reference yield:

: 1261777-72-3
2-(bromomethyl)-4-iodo-1-nitrobenzene

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium carbonate / acetone / 48 h / Reflux

2: palladium diacetate / triethanolamine; N,N-dimethyl-formamide / 12 h / 110 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

With dmap; water; palladium diacetate; sodium carbonate; dicyclohexyl-carbodiimide; In triethanolamine; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Heck reaction;
DOI:10.1039/c2ob25701g