1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

Chemical Name:1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS No.:1566577-87-4
Molecular Formula:C₃₅H₃₃F₃N₆O₆
Molecular Weight:690.679
Hs Code.:

1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Synonyms:1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

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Chemical Property of 1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

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Technology Process of 1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 13 articles about 1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: 1566577-47-6
(E)-5-((dimethylamino)methylene)-1-(2,4-difluorophenyl)pyrimidine-2,4,6-trione

: 1566577-87-4
1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: With acetic acid; at 80 ℃;
DOI:10.1016/j.bmc.2014.01.014

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1566577-87-4
1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 9 steps

1: acetone / 12.5 h / 0 - 20 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: toluene / 10 h / 110 °C

4: iron; acetic acid / 2.5 h / 20 - 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol; water / 5 h / Reflux

9: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.01.014

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 1566577-87-4
1-(2,4-difluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 4 h / 0 °C

2: toluene / 10 h / 110 °C

3: iron; acetic acid / 2.5 h / 20 - 80 °C

4: acetonitrile / 10 h / 85 °C

5: trichlorophosphate / 6 h / 85 °C

6: chlorobenzene / 30 h / 140 °C

7: iron; ammonium chloride / ethanol; water / 5 h / Reflux

8: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.01.014