Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

Base Information

Chemical Name:Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate
CAS No.:1332758-56-1
Molecular Formula:C₂HF₃O₂*C₁₈H₁₉FN₄O₃S
Molecular Weight:504.462
Hs Code.:

Synonyms:Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

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Chemical Property of Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

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Technology Process of Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

There total 4 articles about Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332758-50-5
methyl 4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

: 76-05-1
trifluoroacetic acid

: 1332758-56-1
Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332758-56-1
Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4: dichloromethane / 2 h / 20 °C

With di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1: Mitsunobu reaction;

Reference yield:

: 1332721-17-1
[2-(5-fluoro-2-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 1332758-56-1
Methyl 4-(2-(1-aminopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

3: dichloromethane / 2 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;