(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Base Information

Chemical Name:(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone
CAS No.:1578243-72-7
Molecular Formula:C₃₀H₃₄N₆O₃
Molecular Weight:526.638
Hs Code.:

Synonyms:(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

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Chemical Property of (3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

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Technology Process of (3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

There total 7 articles about (3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1578243-73-8
(3-methoxy-4-((5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

: 1578243-72-7
(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane; water; at 20 ℃; for 1h;

Reference yield:

: 1578245-79-0
tert-butyl 4-(4-(3-chloroisoquinolin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1578243-72-7
(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene; N,N-dimethyl-formamide / 2 h / 140 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol; water / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1578243-56-7
tert-butyl 4-(4-(3-((2-methoxy-4-(3-methoxyazetidine-1-carbonyl)phenyl)amino)isoquinolin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1578243-72-7
(3-methoxy-4-((5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; methanol; water / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; water;