(S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester

Base Information

• Chemical Name: (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester
• CAS No.: 143619-29-8
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.358

Synonyms:(S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester

Chemical Property of (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester

There total 7 articles about (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-methoxyphenyl)prop-2-en-1-one (7448-86-4) + isopropyl 2-cyanopropanoate (30378-24-6) → (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-29-8) + (R)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-29-8)

Guidance literature:

With carbonylhydridetris(triphenylphosphine)rhodium(I); 2,2''-bis<1-(diphenylphosphino)ethyl>-1,1''biferrocene ((S,S)-(R,R)-TRAP); In benzene; at 3 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00047a053

Reference yield:

1-(4-methoxyphenyl)prop-2-en-1-one (7448-86-4) + isopropyl 2-cyanopropanoate (30378-24-6) → (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-29-8) + (R)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-29-8)

Guidance literature:

With carbonylhydridetris(triphenylphosphine)rhodium(I); 2,2''-bis<1-(diphenylphosphino)ethyl>-1,1''biferrocene ((S,S)-(R,R)-TRAP); In benzene; at 3 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00047a053

Reference yield:

1-(4-methoxyphenyl)prop-2-en-1-one (7448-86-4) + isopropyl 2-cyanopropanoate (30378-24-6) → (R)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-29-8)

Guidance literature:

With (S,S)-(R,R)-PhTRAP; (R,R)-CHIRALPHOS ; In benzene; at 3 ℃; for 2h; Yield given;

DOI:10.1016/S0040-4020(01)89377-7

upstream raw materials:

1-(4-methoxyphenyl)prop-2-en-1-one

isopropyl 2-cyanopropanoate

(R)-isopropyl 2-cyano-2-methyl-5-oxopentanoate

4-methoxyphenyl magnesium bromide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143619-29-8 (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send