2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Base Information

Chemical Name:2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline
CAS No.:440363-04-2
Molecular Formula:C₁₂H₁₄F₃NSi
Molecular Weight:257.331
Hs Code.:

Synonyms:2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Suppliers and Price of 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Chemical Property:

Purity/Quality:: More than 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

There total 4 articles about 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 163444-17-5
2-iodo-4-(trifluoromethyl)aniline

: 1066-54-2
trimethylsilylacetylene

: 440363-04-2
2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 20h;
DOI:10.3987/com-01-9411

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 440363-04-2
2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Guidance literature:: Multi-step reaction with 2 steps

1: ICl / dimethylformamide / 0.5 h / 20 °C

2: CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

With copper(l) iodide; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira reaction;
DOI:10.1055/s-2005-922790

Reference yield:

: 878133-04-1
2,2,2-trifluoro-N-(2-iodo-4-(trifluoromethyl)phenyl)acetamide

: 440363-04-2
2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / methanol / 24 h / 50 °C

2: CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; 2: Sonogashira reaction;
DOI:10.1055/s-2005-922790