tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

Base Information

Chemical Name:tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate
CAS No.:1417342-78-9
Molecular Formula:C₃₆H₄₆N₂O₆
Molecular Weight:602.771
Hs Code.:

Synonyms:tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

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Chemical Property of tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

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Technology Process of tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

There total 3 articles about tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 3-(4-benzyloxybutoxy)-3-o-tolylazetidine trifluoroacetate

: 68856-96-2
N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

: 1417342-78-9
tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

Guidance literature:: N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.25h;

3-(4-benzyloxybutoxy)-3-o-tolylazetidine trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1225439-73-5
tert-butyl 3-hydroxy-3-(o-tolyl)azetidine-1-carboxylate

: 1417342-78-9
tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 15 h / 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h

3.2: 0.25 h / 20 °C

3.3: 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 33872-80-9
o-tolyl magnesium chloride

: 1417342-78-9
tert-butyl [(R)-2-[3-(4-benzyloxybutoxy)-3-o-tolylazetidin-1-yl]-1-(4-methoxybenzyl)-2-oxoethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1.5 h / -78 °C

2.1: N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 15 h / 20 °C

3.1: dichloromethane / 1 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h

4.2: 0.25 h / 20 °C

4.3: 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;