33872-80-9

Usage

Chemical Properties

Brown liquid

InChI:InChI=1/C7H7.ClH.Mg/c1-7-5-3-2-4-6-7;;/h2-5H,1H3;1H;/q-1;;+2/p-1

Upstream product

• 98-56-6 4-chlorobenzotrifluoride 
• 95-49-8 2-methylchlorobenzene 
• 7439-95-4 magnesium 
• 615-37-2 ortho-methylphenyl iodide 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 18181-25-4 9-(ortho-tolyl)-9H-fluorene 
• 20685-09-0 9-(2-methylphenyl)-9H-fluoren-9-ol 
• 643-58-3 2-methylbiphenyl 
• 24785-42-0 1-(2,2-Dimethylpropyl)-2-methylbenzene 
• 100223-10-7 methyl 2-acetamido-3-o-tolylpropanoate 
• 53092-64-1 2,2”-dimethyl-1,1‘:4’,1“-terphenyl 
• 605-39-0 2,2'-dimethyl-1,1'-biphenyl 
• 133055-08-0 1-(2,2-Dimethyl-3-phenylpropyl)-2-methylbenzene 
• 126378-54-9 (R)-4-Oxo-2-o-tolyl-5-trimethylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-54-9 (S)-4-Oxo-2-o-tolyl-5-trimethylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-63-0 (R)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-63-0 (S)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 312-03-8 Di-o-tolyldifluorosilane 
• 85674-67-5 1-(3-chloropropyl)-2-methylbenzene 

Relevant academic research and scientific papers

PROCESS FOR SYNTHESIS OF PICOLINAMIDES

The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.

Regioselective 1,4-conjugate addition of grignard reagents to nitrodienes in the presence of catalytic amounts of Zn(II) salts

Grignard reagents undergo facile regioselective 1,4-conjugate addition to nitrodienes in the presence of catalytic amounts of Zn(II) salts with excellent yields. A wide range of ligands such as alkyl, aryl, heteroaryl, allyl, vinyl, 1-alkynyl, and alkoxy ligands were transferred, while a thiolate ligand afforded 1,6-regioselectivity. The reactions were successfully carried out on δ-alkyl- or aryl-substituted α,β,γ,δ-diunsaturated nitrodiene substrates. Regioselectivity is minimally influenced by temperature or choice of solvent.

METHOD FOR PRODUCING BIPHENYL DERIVATIVE

Provided is a method for producing a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. More specifically, the method for producing the biphenyl derivative represented by general formula (1) is characterized in that a chlorine atom in a benzene derivative represented by general formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane: and (wherein A represents at least one selected from alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, phenyl groups and chlorine, and n represents an integer of 1 to 4).

Process safety evaluation of a magnesium-iodine exchange reaction

An unexpected highly exothermic decomposition was observed during routine safety analysis of the magnesium-iodine exchange reaction of 2-iodo-4-fluorotoluene (3) with commercially available i-PrMgCl (2.0 M solution in THF). When the reaction mixture was scanned in an adiabatic calorimeter with the use of a 2 °C/min temperature ramp, a rapid exothermic decomposition with an onset temperature of approximately 80 °C was observed. The system temperature rapidly rose to 210 °C at a peak rate of 200 °C/min. Subsequent testing of three simplified substrates showed the same type of exothermic decomposition for all cases. Control experiments indicated that the decomposition requires both aryl iodide and i-PrMgCl (or arylMgCl and i-PrI). While the onset temperatures for all cases studied were generally well above the typical operating temperature for these reactions (0-10 °C), it is nonetheless important to cautiously evaluate these types of processes and install proper engineering controls for analogous decomposition events.

Production methods of alpha, alpha, alpha-trifluoromethylphenyl-substituted benzoic acid and intermediate therefor

The present invention relates to a production method of compound [V] useful as an intermediate for medicaments and agrochemicals. The method includes reacting compound [III] with hexamethylenetetramine under heating to give compound [IV], and oxidizing the obtained compound [IV] with a halous acid salt or a ruthenium compound. According to the present invention, moreover, an organometallic compound having a tolyl group and compound [I] are cross-coupled in the presence of a catalyst to give compound [II] useful as an intermediate for medicaments and agrochemicals. The compound [II] is halogenated to give compound [III]. wherein X is halogen atom.

Process for preparing 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethyl-biphenyl-2-carboxylic acid from o-tolylmetallates

The invention relates to a process for preparing a compound of the formula (I) in which R is methyl or carboxyl, which comprises coupling an ortho-tolylmetallate of the formula (II) with a compound of the formula (III) in which M is —MgF, —MgCl, —MgBr, —Mgl, —Li, —ZnF, —ZnCl, —ZnBr or —Znl and X is F, Cl, Br, I, N2+, straight-chain or branched (C1-C20)-alkoxy, arylsulfonate or alkylsulfonate in the presence of an Ni, Pd or platinum metal catalyst to give a compound of the formula (I) where R is CH3 and, if appropriate, oxidizing the compound of the formula (I) where R is CH3 to give the compound of the formula (I) where R is carboxyl.