33872-80-9

Basic information

• Product Name: O-TOLYLMAGNESIUM CHLORIDE
• Synonyms: o-TolylMagnesiuM chloride, 1.4 M solution in THF/toluene(82/18), J&KSeal;Chloro(2-tolyl)magnesium;o-TolylMagnesiuM chloride, 1.0 M solution in THF, SpcSeal;o-TolylMagnesiuM chloride, 1.4 M solution in THF/toluene(82/18), SpcSeal;o-Tolylmagnesium chloride solution, 1.4 M solution in THF/toluene(82/18), HySeal;Magnesium,chloro(2-methylphenyl)-;O-cresol phenylmagnesium chloride tetrahydrofuran / toluene (82/18) 1.4M;O-TOLYLMAGNESIUM CHLORIDE
• CAS NO: 33872-80-9
• Molecular Formula: C₇H₇ClMg
• Molecular Weight: 150.89
• EINECS: 251-709-9
• Product Categories: Grignard Reagent
• Mol File: 33872-80-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 110.6°C at 760 mmHg
• Flash Point: −2 °F
• Appearance: /
• Density: 0.96 g/mL at 20 °C
• Vapor Pressure: 27.7mmHg at 25°C
• BRN: 3537703
• CAS DataBase Reference: O-TOLYLMAGNESIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-TOLYLMAGNESIUM CHLORIDE(33872-80-9)
• EPA Substance Registry System: O-TOLYLMAGNESIUM CHLORIDE(33872-80-9)

Safety Data

• Hazard Codes: F,C
• Statements: 14-19-20/21/22-32-34-11-37-40
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3399 4.3/PG 2
• WGK Germany: 3
• F: 1-3-10
• Hazardous Substances Data: 33872-80-9(Hazardous Substances Data)

Usage

Chemical Properties

Brown liquid

InChI:InChI=1/C7H7.ClH.Mg/c1-7-5-3-2-4-6-7;;/h2-5H,1H3;1H;/q-1;;+2/p-1

Upstream product

• 98-56-6 4-chlorobenzotrifluoride 
• 615-37-2 ortho-methylphenyl iodide 
• 95-49-8 2-methylchlorobenzene 
• 95-46-5 2-methylphenyl bromide 
• 7439-95-4 magnesium 

Downstream Products

• 36042-94-1 bis(o-tolyl)chlorophosphine 
• 22077-56-1 di-2-tolyl selenide 
• 16939-08-5 3-(2-methylphenyl)thiophene 
• 10273-89-9 2-(2-methylphenyl)pyridine 
• 605-39-0 2,2'-dimethyl-1,1'-biphenyl 
• 56917-39-6 4-acetyl-2'-methylbiphenyl 
• 643-58-3 2-methylbiphenyl 
• 342416-99-3 6-chloro-4-o-tolyl-nicotinic acid 
• 902750-90-7 (1R,3E,4S)-3-(2-methylbenzylidene)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 4501-35-3 1-cyclohexyl-2-methylbenzene 
• 142603-49-4 2,4,5-trifluoro-6-methylisophthalic acid 
• 342416-97-1 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide 
• 66644-67-5 ethyl 2-methylbenzoylformate 
• 2040-21-3 2'-methylisobutyrophenone 

Relevant articles and documents

PROCESS FOR SYNTHESIS OF PICOLINAMIDES

The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.

METHOD FOR PRODUCING BIPHENYL DERIVATIVE

Provided is a method for producing a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. More specifically, the method for producing the biphenyl derivative represented by general formula (1) is characterized in that a chlorine atom in a benzene derivative represented by general formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane: and (wherein A represents at least one selected from alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, phenyl groups and chlorine, and n represents an integer of 1 to 4).

Production methods of alpha, alpha, alpha-trifluoromethylphenyl-substituted benzoic acid and intermediate therefor

The present invention relates to a production method of compound [V] useful as an intermediate for medicaments and agrochemicals. The method includes reacting compound [III] with hexamethylenetetramine under heating to give compound [IV], and oxidizing the obtained compound [IV] with a halous acid salt or a ruthenium compound. According to the present invention, moreover, an organometallic compound having a tolyl group and compound [I] are cross-coupled in the presence of a catalyst to give compound [II] useful as an intermediate for medicaments and agrochemicals. The compound [II] is halogenated to give compound [III]. wherein X is halogen atom.