N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

Base Information

Chemical Name:N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide
CAS No.:1620518-27-5
Molecular Formula:C₁₉H₁₇NO₃S
Molecular Weight:339.415
Hs Code.:

Synonyms:N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

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Chemical Property of N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

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Technology Process of N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

There total 4 articles about N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1620518-23-1
N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

: 1620518-27-5
N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 58777-65-4
4-Bromothiophene-2-carboxylic acid chloride

: 1620518-27-5
N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

3: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; caesium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 16694-18-1
4-bromo-thiophene-2-carboxylic acid

: 1620518-27-5
N-(3-hydroxybenzyl)-4-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / 110 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

4: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; boron dimethyl-trifluoro sulphide; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036