N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

Base Information

Chemical Name:N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
CAS No.:1620518-23-1
Molecular Formula:C₂₁H₂₁NO₃S
Molecular Weight:367.469
Hs Code.:

Synonyms:N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

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Chemical Property of N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

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Technology Process of N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

There total 3 articles about N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1620518-19-5
4-bromo-N-(3-methoxybenzyl)-N-methylthiophene-2-carboxamide

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1620518-23-1
N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.333333h; Sealed tube; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 58777-65-4
4-Bromothiophene-2-carboxylic acid chloride

: 1620518-23-1
N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 16694-18-1
4-bromo-thiophene-2-carboxylic acid

: 1620518-23-1
N-(3-methoxybenzyl)-4-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / 110 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036