1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

Base Information

Chemical Name:1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol
CAS No.:1050394-71-2
Molecular Formula:C₂₀H₂₀F₃NO
Molecular Weight:347.38
Hs Code.:

Synonyms:1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

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Chemical Property of 1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

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Technology Process of 1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

There total 8 articles about 1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1050394-71-2
1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

5.1: acetic acid / tetrahydrofuran; methanol / 0.17 h / 20 °C

5.2: 84 h

6.1: titanium(IV) isopropylate / tetrahydrofuran / 15 h / 20 °C

6.2: 0.5 h / 0 °C

With titanium(IV) isopropylate; hydrogenchloride; hydrogen; acetic acid; triethylamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate;

Reference yield:

: 1050394-66-5
(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester

: 925-90-6
ethylmagnesium bromide

: 1050394-71-2
1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

Guidance literature:: (2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester; ethylmagnesium bromide; With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 937400-23-2
(R)-2-tert-butoxycarbonylamino-5-oxo-5-(3,4,5-trifluorophenyl)pentanoic acid ethyl ester

: 1050394-71-2
1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3.1: acetic acid / tetrahydrofuran; methanol / 0.17 h / 20 °C

3.2: 84 h

4.1: titanium(IV) isopropylate / tetrahydrofuran / 15 h / 20 °C

4.2: 0.5 h / 0 °C

With titanium(IV) isopropylate; hydrogenchloride; hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate;