5-Oxo-1-(phenylsulphonyl)-L-proline

Base Information

Chemical Name:5-Oxo-1-(phenylsulphonyl)-L-proline
CAS No.:46857-11-8
Molecular Formula:C11H11NO5S
Molecular Weight:269.278
Hs Code.:
European Community (EC) Number:256-284-3
DSSTox Substance ID:DTXSID90196966
Nikkaji Number:J1.831.099F
Wikidata:Q83069939
Mol file:46857-11-8.mol

Synonyms:46857-11-8;5-Oxo-1-(phenylsulphonyl)-L-proline;EINECS 256-284-3;5-OXO-1-(PHENYLSULFONYL)-L-PROLINE;DTXSID90196966;1-(Phenylsulfonyl)pyroglutamic acid;(S)-5-Oxo-1-(phenylsulfonyl)pyrrolidine-2-carboxylic acid

Suppliers and Price of 5-Oxo-1-(phenylsulphonyl)-L-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-Oxo-1-(phenylsulphonyl)-L-proline

Chemical Property:

Vapor Pressure:1.16E-10mmHg at 25°C
Boiling Point:496.2°C at 760 mmHg
Flash Point:253.9°C
PSA：100.13000
Density:1.531g/cm³
LogP:1.46960
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:269.03579362
Heavy Atom Count:18
Complexity:447

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)N(C1C(=O)O)S(=O)(=O)C2=CC=CC=C2
Isomeric SMILES:C1CC(=O)N([C@@H]1C(=O)O)S(=O)(=O)C2=CC=CC=C2

Technology Process of 5-Oxo-1-(phenylsulphonyl)-L-proline

There total 9 articles about 5-Oxo-1-(phenylsulphonyl)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 378238-37-0
tert-butyl N-benzenesulfonyl-(S)-pyroglutamate

: 46857-11-8
1-(benzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/S0040-4020(01)00684-6

Reference yield: 69.78%

: 20531-36-6
2-(benzenesulfonyl)-L-glutamic acid

: 46857-11-8
1-(benzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: With acetyl chloride; for 2h; Heating;
DOI:10.1016/S0968-0896(02)00079-2

Reference yield:

: 35418-16-7,85136-12-5
L-t-butyl pyroglutamate

: 46857-11-8
1-(benzenesulfonyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / NaH / tetrahydrofuran / 1 h / 20 °C

2: 76 percent / trifluoroacetic acid / CH₂Cl₂ / 15 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(03)00420-4