(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Base Information

Chemical Name:(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453069-00-5
Molecular Formula:C₃₀H₃₅F₆N₃O₅
Molecular Weight:631.615
Hs Code.:

(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Synonyms:(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Property of (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Technology Process of (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 14 articles about (1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1453069-98-1
(1S,8aS)-7,7-diallyl-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

: 1453069-00-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: (1S,8aS)-7,7-diallyl-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide; With oxygen; ozone; In dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In dichloromethane; at -78 - 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1453069-00-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) isopropylate / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

3.2: 3 h / -60 - 20 °C

4.1: hydrogenchloride / methanol / 0.25 h / Inert atmosphere

5.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

5.2: 48 h / 50 °C

6.1: ozone; oxygen / dichloromethane / -78 °C

6.2: 20 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; dmap; oxygen; ozone; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 1453069-92-5
(S)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-2-methylpropane-2-sulfinamide

: 1453069-00-5
(1S,8aS)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethyl)-7,7-bis(2-hydroxyethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

1.2: 3 h / -60 - 20 °C

2.1: hydrogenchloride / methanol / 0.25 h / Inert atmosphere

3.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

3.2: 48 h / 50 °C

4.1: ozone; oxygen / dichloromethane / -78 °C

4.2: 20 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; oxygen; ozone; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;