dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate

Base Information

• Chemical Name: dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate
• CAS No.: 1029873-08-2
• Molecular Formula: C₂₀H₃₂O₅Si
• Molecular Weight: 380.557
• Mol file: 1029873-08-2.mol

Synonyms:dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate

Chemical Property of dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate

There total 1 articles about dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cyclohexenone (930-68-7) + t-butyldimethylsiyl triflate (69739-34-0) + dimethyl (prop-2-yn-1-yl)malonate (95124-07-5) → dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate (1029873-08-2)

Guidance literature:

dimethyl (prop-2-yn-1-yl)malonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

cyclohexenone; t-butyldimethylsiyl triflate; In tetrahydrofuran; at 20 ℃; for 2h; Further stages.;

DOI:10.1002/adsc.200700304

Reference yield:

dimethyl (3-tert-butyldimethylsilyloxy-2-cyclohexen-1-yl)(propargyl)malonate (1029873-08-2) → 2-(3-oxocyclohexyl)-2-prop-2-ynylmalonic acid dimethyl ester (868388-66-3) + 3-methyl-4-oxo-2,4,5,6,7,7a-hexahydro-indene-1,1-dicarboxylic acid dimethyl ester

Guidance literature:

With water; gold(III) chloride; In dichloromethane; at 25 ℃; for 0.0833333h;

DOI:10.1002/adsc.200700304

upstream raw materials:

cyclohexenone

t-butyldimethylsiyl triflate

dimethyl (prop-2-yn-1-yl)malonate

Downstream raw materials:

2-(3-oxocyclohexyl)-2-prop-2-ynylmalonic acid dimethyl ester