4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester

Base Information

• Chemical Name: 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester
• CAS No.: 200562-69-2
• Molecular Formula: C₁₇H₂₁F₃O₅
• Molecular Weight: 362.346
• Mol file: 200562-69-2.mol

Synonyms:4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester

Chemical Property of 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester

There total 2 articles about 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4-(methoxycarbonyloxy)benzoic acid (14180-11-1) + (2R)-1,1,1-trifluorooctan-2-ol (121170-45-4) → 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester (200562-69-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; for 50h; Ambient temperature;

DOI:10.1246/cl.1996.583

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → 4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester (200562-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / NaOH / H₂O / 0.5 h / 4 °C

2: 25 percent / diethyl azodicarboxylate, PPh₃ / diethyl ether / 50 h / Ambient temperature

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In diethyl ether; water;

DOI:10.1246/cl.1996.583

Reference yield: 89.0%

4-Methoxycarbonyloxy-benzoic acid (S)-1-trifluoromethyl-heptyl ester (200562-69-2) → (S)-(-)-1-(trifluoromethyl)heptyl p-hydroxybenzoate (128054-74-0)

Guidance literature:

With ammonium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1246/cl.1996.583

upstream raw materials:

4-(methoxycarbonyloxy)benzoic acid

(2R)-1,1,1-trifluorooctan-2-ol

4-hydroxy-benzoic acid

Downstream raw materials:

(S)-(-)-1-(trifluoromethyl)heptyl p-hydroxybenzoate