(R,E)-2-styryltetrahydrofuran

Base Information

• Chemical Name: (R,E)-2-styryltetrahydrofuran
• CAS No.: 897387-94-9
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.243
• Mol file: 897387-94-9.mol

Synonyms:(R,E)-2-styryltetrahydrofuran

Chemical Property of (R,E)-2-styryltetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-2-styryltetrahydrofuran

There total 5 articles about (R,E)-2-styryltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-phenylhex-5-yn-1-ol (69936-53-4) → (S,E)-2-styryltetrahydrofuran + (R,E)-2-styryltetrahydrofuran (897387-94-9)

Guidance literature:

With (R,R)-2-exo-3-endo-bis(diphenylphosphino)bicyclo-[2.2.1]-heptane; benzoic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In benzene; at 100 ℃; for 72h; Title compound not separated from byproducts;

DOI:10.1021/jo0603835

Reference yield:

iodobenzene (591-50-4) → (R,E)-2-styryltetrahydrofuran (897387-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CuI; triethylamine / Pd(PPh₃)4 / 20 °C

2: benzoic acid; (R,R)-renorphos / Pd₂(dba)3*CHCl₃ / benzene / 72 h / 100 °C

With copper(l) iodide; (R,R)-2-exo-3-endo-bis(diphenylphosphino)bicyclo-[2.2.1]-heptane; triethylamine; benzoic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; 1: Sonogashira reaction;

DOI:10.1021/jo0603835

Reference yield:

5-hexyl-1-ol (928-90-5) → (R,E)-2-styryltetrahydrofuran (897387-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CuI; triethylamine / Pd(PPh₃)4 / 20 °C

2: benzoic acid; (R,R)-renorphos / Pd₂(dba)3*CHCl₃ / benzene / 72 h / 100 °C

With copper(l) iodide; (R,R)-2-exo-3-endo-bis(diphenylphosphino)bicyclo-[2.2.1]-heptane; triethylamine; benzoic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; 1: Sonogashira reaction;

DOI:10.1021/jo0603835

upstream raw materials:

6-phenylhex-5-yn-1-ol

iodobenzene

5-hexyl-1-ol

styrene