(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate
CAS No.:1104070-03-2
Molecular Formula:C₁₆H₂₃F₂NO₃
Molecular Weight:315.36
Hs Code.:

Synonyms:(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

Suppliers and Price of (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

There total 1 articles about (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1104070-00-9
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(1,1-difluoroethyl)phenyl)propanoate

: 1104070-03-2
(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

Guidance literature:: (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(1,1-difluoroethyl)phenyl)propanoate; With lithium borohydride; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 2h;

With sodium dihydrogenphosphate; water; In tetrahydrofuran; ethanol;

Reference yield:

: 1104070-03-2
(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

: 1104070-06-5
1,1-dimethylethyl (4S)-4-((4-(1,1-difluoroethyl)phenyl)methyl)-1,2,3-oxathiazolidine-3-carboxylate 2-oxide

Guidance literature:: (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate; With thionyl chloride; In dichloromethane; acetonitrile; at -60 ℃;

With pyridine; In dichloromethane; acetonitrile; at -60 - 20 ℃;

Reference yield:

: 1104070-03-2
(S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate

: (S)-tert-butyl-(S)-4-(4-(1,1-difluoroethy)lbenzyl)-1,2,3-oxathiazolidine-3-carboxylate-2-oxide

: (R)-tert-butyl-(S)-4-(4-(1,1-difluoroethyl)benzyl)-1,2,3-oxathiazolidine-3-carboxylate-2-oxide

Guidance literature:: (S)-tert-butyl 3-(4-(1,1-difluoroethyl)phenyl)-1-hydroxypropan-2-ylcarbamate; With thionyl chloride; In dichloromethane; acetonitrile; at -60 ℃; for 0.166667h;

With pyridine; In dichloromethane; acetonitrile; at -60 - 20 ℃;

With sodium dihydrogenphosphate; water; In dichloromethane; acetonitrile;