(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester
CAS No.:175272-69-2
Molecular Formula:C₁₇H₂₀F₃NO₄
Molecular Weight:359.345
Hs Code.:

Synonyms:(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Suppliers and Price of (3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
(3S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylicacid
5g
$ 7370.00

Alichem
(3S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylicacid
1g
$ 2787.20

Total 2 raw suppliers

Chemical Property of (3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

There total 6 articles about (3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60689-14-7,64379-91-5
trans-3-(trifluoromethyl)cinnamoyl chloride

: 175272-69-2
(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, 2.) CuCl / 1.) toluene

2: CH₂Cl₂

3: H₂ / Pd/C / 760 Torr

4: methanol

5: LiOH*H₂O / tetrahydrofuran; H₂O

With lithium hydroxide; hydrogen; sodium hydride; copper(l) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/0960-894X(96)00015-7

Reference yield:

: 175028-03-2
(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(3-trifluoromethyl-phenyl)-propenone

: 175272-69-2
(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂

2: H₂ / Pd/C / 760 Torr

3: methanol

4: LiOH*H₂O / tetrahydrofuran; H₂O

With lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/0960-894X(96)00015-7

Reference yield:

: 175028-04-3
[(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

: 175272-69-2
(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / 760 Torr

2: methanol

3: LiOH*H₂O / tetrahydrofuran; H₂O

With lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1016/0960-894X(96)00015-7