Technology Process of 1-(2,6-dibromophenylazo)pyrrolidine
There total 1 articles about 1-(2,6-dibromophenylazo)pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2,6-dibromophenylazo)pyrrolidine;
With
TurboGrignard;
In
tetrahydrofuran;
at -40 - -15 ℃;
for 4h;
With
zinc dibromide;
In
tetrahydrofuran;
at -20 - 5 ℃;
for 1h;
2-bromo-pyridine;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
for 16h;
Reflux;
DOI:10.1002/chem.202003271
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C / Inert atmosphere
1.3: 72 h / Reflux; Inert atmosphere
2.1: iodine / 1,2-dichloro-ethane / Reflux; Inert atmosphere
3.1: iodine; magnesium / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
3.2: 24 h / Reflux; Inert atmosphere
3.3: 8.5 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
4.2: 1.5 h / -78 - 20 °C / Inert atmosphere
5.1: benzene-d6 / 16 h / 20 °C / Inert atmosphere
With
n-butyllithium; iodine; magnesium;
In
tetrahydrofuran; hexane; benzene-d6; 1,2-dichloro-ethane;
1.3: Negishi coupling reaction;
DOI:10.1021/ja2040392
