Technology Process of C19H15F3N2O3
There total 6 articles about C19H15F3N2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C11H9F3N2O;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
Inert atmosphere;
benzyl chloroformate;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
With
ammonia;
In
methanol; water;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: water; iron; ammonium chloride / ethanol / 0.83 h / 100 - 105 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
2.2: 0 - 20 °C
2.3: 2 h / 20 °C
With
water; iron; sodium hydride; ammonium chloride;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / 1-methylpiperidin-2-one / -10 - 20 °C
2.1: triethylamine / tetrahydrofuran / 2.67 h / 0 - 20 °C
3.1: ammonium cerium(IV) nitrate / N,N-dimethyl-formamide / 4 h / 0 - 20 °C
4.1: water; iron; ammonium chloride / ethanol / 0.83 h / 100 - 105 °C
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
5.2: 0 - 20 °C
5.3: 2 h / 20 °C
With
ammonium cerium(IV) nitrate; water; iron; sodium hydride; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1-methylpiperidin-2-one; ethanol; N,N-dimethyl-formamide;