ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

Base Information

Chemical Name:ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate
CAS No.:165808-20-8
Molecular Formula:C₂₇H₂₈N₂O₆S₂
Molecular Weight:540.661
Hs Code.:

Synonyms:ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

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Chemical Property of ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

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Technology Process of ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

There total 9 articles about ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 107-30-2
chloromethyl methyl ether

: 165808-07-1
ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

: 165808-20-8
ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

Guidance literature:: In N-methyl-acetamide; nitrogen;

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 165808-20-8
ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 8 steps

1: NH₄OAc, AcOH / benzene / 24 h / Heating

2: S, Et₂NH / ethanol / 2 h / 60 °C

3: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

4: 85 percent / AlCl₃, dimethyl disulfide / CH₂Cl₂ / 20 h / Ambient temperature

5: pyridine / 3 h / Ambient temperature

6: K₂CO₃ / dimethylformamide / 13 h / Ambient temperature

7: 78 percent / aq. K₂CO₃ / methanol; tetrahydrofuran / 0.67 h / Ambient temperature

8: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

With pyridine; aluminium trichloride; Dimethyldisulphide; ammonium acetate; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; diethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.46.1724

Reference yield:

: 26190-68-1
1-chloromethyl-2-methylsulfanylbenzene

: 165808-20-8
ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 13 h / Ambient temperature

2: 78 percent / aq. K₂CO₃ / methanol; tetrahydrofuran / 0.67 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

With sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724