26190-68-1

Basic information

• Product Name: Benzene, 1-(chloromethyl)-2-(methylthio)-
• CAS NO: 26190-68-1
• Molecular Formula: C8H9ClS
• Molecular Weight: 172.678
• Mol File: 26190-68-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(chloromethyl)-2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(chloromethyl)-2-(methylthio)-(26190-68-1)
• EPA Substance Registry System: Benzene, 1-(chloromethyl)-2-(methylthio)-(26190-68-1)

Safety Data

• Hazardous Substances Data: 26190-68-1(Hazardous Substances Data)

Upstream product

• 3704-28-7 methyl 2-(methylthio)benzoate 
• 4521-40-8 2-chloromethyl-benzenethiol 
• 74-88-4 methyl iodide 
• 1442-00-8 ethyl 2-(methylthio)benzoate 
• 3724-10-5 2-(methylthio)benzoic acid 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 147-93-3 Thiosalicylic acid 
• 118-92-3 anthranilic acid 

Downstream Products

• 7022-45-9 2-(methylsulfanyl)benzaldehyde 
• 134749-75-0 [(2-Methylsulfanyl-phenyl)-phenylmethanesulfonyl-methylene]-triphenyl-λ⁵-phosphane 
• 125177-53-9 Methyl 4-(2-methylthiobenzyl)-1-piperazinecarbodithioate 
• 165807-97-6 [6-(4-butyryl-phenyl)-5-methyl-1-(2-methylsulfanyl-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester 
• 165808-27-5 ethyl 6-(4-acetoxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 165807-77-2 [5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-nitro-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester 
• 165807-75-0 ethyl 2,4(1H,3H)-dioxo-6-(4-methoxyphenyl)-1-(2-methylthiobenzyl)-5-methylthieno[2,3-d]-pyrimidine-3-acetate 
• 165809-36-9 ethyl 2,4(1H,3H)-dioxo-6-bromo-5-methyl-1-(2-methylthiobenzyl)thieno[2,3-d]pyrimidine-3-acetate 
• 65442-16-2 1-chloromethyl-2-methanesulfinylbenzene 
• 81580-97-4 2-methylthio-4′-methoxy-trans-stilbene 
• 81580-99-6 (E)-4-ethoxy-2'-methylthiostilbene 
• 83863-51-8 C₈H₉NO₂S 
• 1206710-33-9 [(o-MeSC₆H₄)CH₂]2SnPhCl 
• 1206710-32-8 [(o-MeSC₆H₄)CH₂]2SnPh₂ 

Relevant articles and documents

Enhanced stereoselectivity of a Cu(II) complex chiral auxiliary in the synthesis of Fmoc-L-γ-carboxyglutamic acid

L-γ-Carboxyglutamic acid (Gla) is an uncommon amino acid that binds avidly to mineral surfaces and metal ions. Herein, we report the synthesis of N-R-Fmoc-L-γ-carboxyglutamic acid γ, γ0-tert-butyl ester (Fmoc-Gla(OtBu)2-OH), a suitably protected analogue for Fmoc-based solid-phase peptide synthesis. The residue was synthesized using a novel chiral Cu(II) complex, whose structurebased design was inspired by the blue copper protein rusticyanin. The five-coordinate complex is formed by Shiff base formation between glycine and the novel ligand (S)-2-(N-(2-methylthio)benzylprolyl) aminobenzophenone in the presence of copper. Michael addition of di-tert-butyl methylenemalonate to the R-carbon of the glycine portion of the complex occurs in a diastereoselective fashion. The resulting (S,S)-complex diastereomer can be easily purified by chromatography. Metal complex decomposition followed by Fmoc protection affords the enantiomerically pure amino acid. With the use of this novel chiral complex, the asymmetric synthesis of Fmoc-Gla(OtBu)2-OH was completed in nine steps from thiosalicylic acid in 14.5% overall yield.

Flash vacuum pyrolysis of stabilised phosphorus ylides. Part 12. Extrusion of Ph3P from sulfonyl ylides and reactivity of the resulting sulfonyl carbenes

Twelve sulfonyl stabilised phosphorus ylides have been prepared and their behaviour upon flash vacuum pyrolysis at 600°C has been examined. Examples with an arylsulfonyl substituent undergo loss of Ph3PO to give intractable products but those with an arylmethylsulfonyl substituent separately lose Ph3P and SO2 to give products consistent with the intermediacy of sulfonyl carbenes. X-Ray structure determinations of one ylide from each series show a more significant P-O non-bonding interaction in the first case, providing some explanation for the different thermal reactivity.