Technology Process of N-(3-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)propyl)-2-chloro-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
There total 18 articles about N-(3-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)propyl)-2-chloro-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron; ammonium chloride;
In
methanol; water;
at 65 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: diethyl ether; tetrahydrofuran / 2.5 h / 0 °C / Reflux
2.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C
3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
3.2: 3 h / 25 °C
4.1: potassium hydroxide / water / 20 °C
5.1: hydrogenchloride; water / 1 h / Reflux
6.1: ammonia / water / 5 h / Heating
7.1: trichlorophosphate / 1 h / 110 °C / microwave irradiation
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
9.1: ammonium chloride; iron / water; methanol / 2 h / 65 °C
With
hydrogenchloride; n-butyllithium; formic acid; ammonia; water; dihydrogen peroxide; iron; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; hexanes; diethyl ether; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: diethyl ether; tetrahydrofuran / 2.5 h / 0 °C / Reflux
2.1: formic acid; dihydrogen peroxide / 4 h / 20 - 40 °C
3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
3.2: 3 h / 25 °C
4.1: potassium hydroxide / water / 20 °C
5.1: hydrogenchloride; water / 1 h / Reflux
6.1: ammonia / water / 5 h / Heating
7.1: trichlorophosphate / 1 h / 110 °C / microwave irradiation
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C
9.1: ammonium chloride; iron / water; methanol / 2 h / 65 °C
With
hydrogenchloride; n-butyllithium; formic acid; ammonia; water; dihydrogen peroxide; iron; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; hexanes; diethyl ether; water; acetonitrile;
![2-chloro-N-methyl-N-(3-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)propyl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine](/Databaselist/images/loading.webp)
