6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid

Base Information

Chemical Name:6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid
CAS No.:54643-79-7
Molecular Formula:C15H8Cl2N2O2
Molecular Weight:319.14
Hs Code.:2933997500
European Community (EC) Number:641-716-9
UNII:DYN1NC1YTQ
DSSTox Substance ID:DTXSID80203077
Nikkaji Number:J1.452.113E
Wikidata:Q27276671
Mol file:54643-79-7.mol

Synonyms:54643-79-7;6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid;6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxylic acid;6-Chloro-4-(o-chlorophenyl)-2-quinazolinecarboxylic Acid;DYN1NC1YTQ;WY-17033;2-Quinazolinecarboxylic acid, 6-chloro-4-(2-chlorophenyl)-;UNII-DYN1NC1YTQ;Lorazepam Related Compound D;DTXSID80203077;TQP1344;AKOS027320698;CS-0453464;FT-0664574;A899761;Q27276671;6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxylicacid;6-chloro-4-(o-chloro-phenyl)-2-quinazolinecarboxylic acid

Suppliers and Price of 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylicAcid
250mg
$ 1390.00

Sigma-Aldrich
Lorazepam Related Compound D United States Pharmacopeia (USP) Reference Standard
25mg
$ 1160.00

Medical Isotopes, Inc.
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylicAcid
250 mg
$ 2200.00

Biosynth Carbosynth
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid
50 mg
$ 500.00

Biosynth Carbosynth
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid
25 mg
$ 320.00

Biosynth Carbosynth
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid
10 mg
$ 180.00

Biosynth Carbosynth
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid
5 mg
$ 100.00

Biosynth Carbosynth
6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid
2 mg
$ 70.00

American Custom Chemicals Corporation
6-CHLORO-4-(2-CHLOROPHENYL)-2-QUINAZOLINE CARBOXYLIC ACID 95.00%
5MG
$ 501.48

Total 8 raw suppliers

Chemical Property of 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid

Chemical Property:

Melting Point:218-219 °C (decomp)
Boiling Point:534.7±60.0 °C(Predicted)
PKA:3.66±0.50(Predicted)
PSA：63.08000
Density:1.507±0.06 g/cm3(Predicted)
LogP:4.30180
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:317.9962829
Heavy Atom Count:21
Complexity:396

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): 816764
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NC(=NC3=C2C=C(C=C3)Cl)C(=O)O)Cl
Uses 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid (Lorazepam Related Compound D) is a metabolite of Lorazepam (L469850). 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid is a metabolite of Lorazepam (L469850).

Technology Process of 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid

There total 4 articles about 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 153681-83-5
6-chloro-4-(2-chlorophenyl)-1,2-dihydroquinazoline-2-carboxylic acid

: 54643-79-7
6-chloro-4-(2-chlorophenyl)quinazoline-2-carboxylic acid

Guidance literature:: With air; In N,N-dimethyl-formamide; for 72h; Irradiation;
DOI:10.1016/S0040-4020(01)80432-4

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 54643-79-7
6-chloro-4-(2-chlorophenyl)quinazoline-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent Turnov_. / ammonium acetate / H₂O; ethanol / 0.25 h

2: 2 N NaOH / ethanol / Heating

3: air

With ammonium acetate; sodium hydroxide; air; In ethanol; water;
DOI:10.1016/S0040-4020(01)80432-4