tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate

Base Information

• Chemical Name: tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate
• CAS No.: 870678-51-6
• Molecular Formula: C₂₆H₂₇FN₂O₆
• Molecular Weight: 482.509

Synonyms:tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate

Chemical Property of tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate

Chemical Property:

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Technology Process of tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate

There total 5 articles about tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-amino-1-(2,4-dimethoxyphenyl)-5-(4-fluorobenzoyl)pyridin-2(1H)-one (602311-12-6,603106-20-3,603106-21-4) + bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate (870678-51-6)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jo0515428

Reference yield:

3-(4-fluorophenyl)-3-oxopropionitrile (4640-67-9) → tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate (870678-51-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / salicylaldehyde; piperidine / ethanol / Heating

2: methanol / 2 h / 65 °C

3: methanol / 65 °C

4: 72 percent / potassium carbonate / acetone / 48 h / Heating

With potassium carbonate; piperidine; salicylaldehyde; In methanol; ethanol; acetone;

DOI:10.1021/jo0515428

Reference yield:

2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate (870678-51-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / salicylaldehyde; piperidine / ethanol / Heating

2: methanol / 2 h / 65 °C

3: methanol / 65 °C

4: 72 percent / potassium carbonate / acetone / 48 h / Heating

With potassium carbonate; piperidine; salicylaldehyde; In methanol; ethanol; acetone;

DOI:10.1021/jo0515428

upstream raw materials:

6-amino-1-(2,4-dimethoxyphenyl)-5-(4-fluorobenzoyl)pyridin-2(1H)-one

bromoacetic acid tert-butyl ester

(E)-3-Amino-3-(2,4-dimethoxy-phenylamino)-1-(4-fluoro-phenyl)-propenone

methyl (2E,4E)-5-amino-5-[(2,4-dimethoxyphenyl)amino]-4-(4-fluorobenzoyl)penta-2,4-dienoate

Downstream raw materials:

N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

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