N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

Base Information

Chemical Name:N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine
CAS No.:870678-52-7
Molecular Formula:C₂₂H₁₉FN₂O₆
Molecular Weight:426.401
Hs Code.:

Synonyms:N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

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Technology Process of N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

There total 6 articles about N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 870678-51-6
tert-butyl N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycinate

: 870678-52-7
N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jo0515428

Reference yield:

: 4640-67-9
3-(4-fluorophenyl)-3-oxopropionitrile

: 870678-52-7
N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / salicylaldehyde; piperidine / ethanol / Heating

2: methanol / 2 h / 65 °C

3: methanol / 65 °C

4: 72 percent / potassium carbonate / acetone / 48 h / Heating

5: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

With potassium carbonate; trifluoroacetic acid; piperidine; salicylaldehyde; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jo0515428

Reference yield:

: 2735-04-8,161687-55-4
2,4-Dimethoxyaniline

: 870678-52-7
N-[1-(2,4-dimethoxyphenyl)-3-(4-fluorobenzoyl)-6-oxo-1,6-dihydropyridin-2-yl]glycine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / salicylaldehyde; piperidine / ethanol / Heating

2: methanol / 2 h / 65 °C

3: methanol / 65 °C

4: 72 percent / potassium carbonate / acetone / 48 h / Heating

5: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

With potassium carbonate; trifluoroacetic acid; piperidine; salicylaldehyde; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jo0515428