1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole

Base Information

• Chemical Name: 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole
• CAS No.: 117760-51-7
• Molecular Formula: C₃₄H₃₀N₂O₄S₂
• Molecular Weight: 594.755
• Mol file: 117760-51-7.mol

Synonyms:1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole

Chemical Property of 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole

There total 3 articles about 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-phenyl-maleimide (941-69-5) + 3-(1-methylethenyl)-1-phenylsulfonyl-1H-indole (117760-49-3) → 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole (117760-51-7) + 5-methyl-2-phenyl-10-(phenylsulfonyl)-1,2,3,3aβ,4,10,10aβ,10bβ-octahyydropyrrolo<3,4-a>carbazole-1,3-dione

Guidance literature:

With aluminium trichloride; In toluene; at 20 ℃; for 5h;

DOI:10.1002/hlca.19880710220

Reference yield:

indole (120-72-9) → 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole (117760-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / trifluoroacetic acid / 2.5 h / Heating

2: 1) NaH / 1) DMSO, 30 min, 2) 30 min

With sodium hydride; trifluoroacetic acid;

DOI:10.1016/S0040-4020(01)89501-6

Reference yield:

1,1,3-trimethyl-3-(3-indolyl)-1,2,3,4-tetrahydro-cyclopentindole (120551-57-7) + benzenesulfonyl chloride (98-09-9) → 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole (117760-51-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMSO, 30 min, 2) 30 min;

DOI:10.1016/S0040-4020(01)89501-6

upstream raw materials:

N-phenyl-maleimide

3-(1-methylethenyl)-1-phenylsulfonyl-1H-indole

1,1,3-trimethyl-3-(3-indolyl)-1,2,3,4-tetrahydro-cyclopentindole

benzenesulfonyl chloride