(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

Base Information

Chemical Name:(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid
CAS No.:1297546-83-8
Molecular Formula:C₂₁H₂₀Cl₂F₃NO₃
Molecular Weight:462.296
Hs Code.:

Synonyms:(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

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Chemical Property of (+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

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Technology Process of (+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

There total 4 articles about (+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 1297550-98-1
ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

: 1297546-83-8
(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 100 ℃; for 1h;

Reference yield:

: ethyl (E/Z)-3-(4-chloro-3-nitrophenyl)-2-methylprop-2-enoate

: 1297546-83-8
(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate / 6 h / 760.05 Torr

2: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 35 °C / Resolution of racemate

3: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride; acetic acid / water / 1 h / 100 °C

With pyridine; hydrogenchloride; hydrogen; acetic acid; HATU; palladium 10% on activated carbon; In 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1297549-27-9
ethyl (±)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate

: 1297546-83-8
(+)-(2R)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 35 °C / Resolution of racemate

2: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride; acetic acid / water / 1 h / 100 °C

With pyridine; hydrogenchloride; acetic acid; HATU; In 2-Methylpentane; water; N,N-dimethyl-formamide; isopropyl alcohol;