ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

Base Information

Chemical Name:ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate
CAS No.:1297550-98-1
Molecular Formula:C₂₃H₂₄Cl₂F₃NO₃
Molecular Weight:490.35
Hs Code.:

Synonyms:ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

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Chemical Property of ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

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Technology Process of ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

There total 3 articles about ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: 1297549-30-4
ethyl (-)-(2R)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate

: 1297550-98-1
ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

Guidance literature:: With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: ethyl (E/Z)-3-(4-chloro-3-nitrophenyl)-2-methylprop-2-enoate

: 1297550-98-1
ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate / 6 h / 760.05 Torr

2: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 35 °C / Resolution of racemate

3: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; acetic acid; HATU; palladium 10% on activated carbon; In 2-Methylpentane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1297549-27-9
ethyl (±)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate

: 1297550-98-1
ethyl (2R)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Daicel Chiralpak OJ-H / isopropyl alcohol; 2-Methylpentane / 35 °C / Resolution of racemate

2: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; HATU; In 2-Methylpentane; N,N-dimethyl-formamide; isopropyl alcohol;