(2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

Base Information

Chemical Name:(2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine
CAS No.:1104071-30-8
Molecular Formula:C₁₈H₂₃F₃N₂O₃
Molecular Weight:372.387
Hs Code.:

Synonyms:(2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

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Technology Process of (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

There total 1 articles about (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1104071-27-3
(S)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)(4-(trifluoromethyl)phenyl)methanol

: 74-88-4
methyl iodide

: 1104071-30-8
(2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 10 ℃;

Reference yield: 43.0%

: 1104071-30-8
(2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine

: 1104071-31-9
(2S,3S)-methyl 2-amino-3-methoxy-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine; With hydrogenchloride; In tetrahydrofuran; acetonitrile; at 20 ℃;

With sodium hydrogencarbonate; In water; pH=7;