3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

Base Information

Chemical Name:3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide
CAS No.:871656-47-2
Molecular Formula:C₂₆H₃₄N₂O₆S₂Si
Molecular Weight:562.783
Hs Code.:

Synonyms:3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

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Chemical Property of 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

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Technology Process of 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

There total 6 articles about 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 96-50-4
2-thiazolylamine

: 871656-48-3
3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid

: 871656-47-2
3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); for 4h;

Reference yield:

: 871656-49-4
methyl 3-(benzyloxy)-5-(4-(methylsulfonyl)phenoxy)benzoate

: 871656-47-2
3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 4 h

2: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 3.5 h / 45 °C

4: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 4 h

With lithium hydroxide; PS-triphenylphosphine; di-isopropyl azodicarboxylate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 871656-47-2
3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3 h / 120 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 4 h

4: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

5: lithium hydroxide; water / tetrahydrofuran / 3.5 h / 45 °C

6: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 4 h

With lithium hydroxide; PS-triphenylphosphine; di-isopropyl azodicarboxylate; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;