3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid

Base Information

• Chemical Name: 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid
• CAS No.: 871656-48-3
• Molecular Formula: C₂₃H₃₂O₇SSi
• Molecular Weight: 480.654
• Mol file: 871656-48-3.mol

Synonyms:3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid

Chemical Property of 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid

There total 10 articles about 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-((1S)-2-(tert-butyldimethylsiloxy)-1-methylethoxy)-3-(4-methanesulfonylphenoxy)benzoic acid methyl ester (752242-47-0) → 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid (871656-48-3)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 45 ℃; for 3.5h;

Reference yield: 68.0%

C17H18O7S (1001419-70-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid (871656-48-3)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 20h;

Reference yield:

3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester (752242-45-8) → 3-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-benzoic acid (871656-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 3.5 h / 45 °C

With lithium hydroxide; PS-triphenylphosphine; di-isopropyl azodicarboxylate; water; In tetrahydrofuran; dichloromethane;

upstream raw materials:

C₁₇H₁₈O₇S

tert-butyldimethylsilyl chloride

5-((1S)-2-(tert-butyldimethylsiloxy)-1-methylethoxy)-3-(4-methanesulfonylphenoxy)benzoic acid methyl ester

3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester

Downstream raw materials:

C₂₅H₂₆O₈S

C₂₇H₂₃N₃O₇S₂

C₂₇H₂₄N₂O₉S₂

C₂₇H₂₅N₃O₈S₂