Technology Process of (1R,5R,6S)-5-tert-butyldimethylsilyloxy-2-iodo-6-methylcyclohex-2-enol
There total 6 articles about (1R,5R,6S)-5-tert-butyldimethylsilyloxy-2-iodo-6-methylcyclohex-2-enol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(5R,6R)-5-tert-butyldimethylsilyloxy-2-iodo-6-methyl-2-cyclohexenone;
With
sodium tetrahydroborate; cerium(III) chloride heptahydrate;
In
methanol; dichloromethane;
at 0 ℃;
for 0.5h;
With
water; ammonium chloride;
In
methanol; dichloromethane;
stereoselective reaction;
DOI:10.1039/c0ob01118e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dmap; iodine / dichloromethane / 10.3 h / 20 °C
2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol; dichloromethane / 0.5 h / 0 °C
With
dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; iodine;
In
methanol; dichloromethane;
2: Luche reduction;
DOI:10.1039/c0ob01118e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-acetylcystein; diphenyl diselenide; sodium hydroxide / methanol / 1.5 h / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 0 - 20 °C
3.1: ozone / methanol; dichloromethane / -78 °C
3.2: 0.33 h / -20 °C
3.3: 10 h / -20 - 20 °C
4.1: dmap; iodine / dichloromethane / 10.3 h / 20 °C
5.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol; dichloromethane / 0.5 h / 0 °C
With
1H-imidazole; dmap; sodium tetrahydroborate; N-acetylcystein; cerium(III) chloride heptahydrate; diphenyl diselenide; iodine; ozone; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
5.1: Luche reduction;
DOI:10.1039/c0ob01118e