N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

Base Information

• Chemical Name: N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide
• CAS No.: 179096-76-5
• Molecular Formula: C₆₇H₉₃N₃O₇Si₂
• Molecular Weight: 1108.66

Synonyms:N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

Chemical Property of N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

Chemical Property:

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Technology Process of N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

There total 18 articles about N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Isopropylphenol (99-89-8) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (179096-76-5)

Guidance literature:

Multi-step reaction with 9 steps

1: imidazole / dimethylformamide / 3 h / 25 °C

2: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

3: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

4: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

5: imidazole / dimethylformamide / 3 h / 25 °C

6: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

7: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

8: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

9: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With 1H-imidazole; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

Reference yield:

tert-butyl(4-isopropylphenoxy)dimethylsilane (158978-08-6) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (179096-76-5)

Guidance literature:

Multi-step reaction with 8 steps

1: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

2: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

3: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

4: imidazole / dimethylformamide / 3 h / 25 °C

5: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

6: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

7: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

8: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With 1H-imidazole; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

Reference yield:

[4-(1-Azido-1-methyl-ethyl)-phenoxy]-tert-butyl-dimethyl-silane (158978-15-5) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (179096-76-5)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

2: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

3: imidazole / dimethylformamide / 3 h / 25 °C

4: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

5: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

6: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

7: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

upstream raw materials:

N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2,5-dimethyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-N-(1-ethyl-cyclopentyl)-2-[2-(methoxy-methyl-carbamoyl)-ethyl]-benzamide

N-(2-chlorethyl)morpholine

4-Isopropylphenol

Downstream raw materials:

N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

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