N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

Base Information

• Chemical Name: N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide
• CAS No.: 1026747-72-7
• Molecular Formula: C₆₇H₉₅N₃O₇Si₂
• Molecular Weight: 1110.68

Synonyms:N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

Chemical Property of N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

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Technology Process of N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

There total 20 articles about N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Isopropylphenol (99-89-8) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (1026747-72-7)

Guidance literature:

Multi-step reaction with 10 steps

1: imidazole / dimethylformamide / 3 h / 25 °C

2: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

3: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

4: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

5: imidazole / dimethylformamide / 3 h / 25 °C

6: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

7: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

8: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

9: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

10: NaBH₄ / ethanol / 0.75 h

With 1H-imidazole; sodium tetrahydroborate; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

Reference yield:

tert-butyl(4-isopropylphenoxy)dimethylsilane (158978-08-6) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (1026747-72-7)

Guidance literature:

Multi-step reaction with 9 steps

1: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

2: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

3: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

4: imidazole / dimethylformamide / 3 h / 25 °C

5: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

6: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

7: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

8: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

9: NaBH₄ / ethanol / 0.75 h

With 1H-imidazole; sodium tetrahydroborate; trimethylsilylazide; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

Reference yield:

[4-(1-Azido-1-methyl-ethyl)-phenoxy]-tert-butyl-dimethyl-silane (158978-15-5) → N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-hydroxy-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide (1026747-72-7)

Guidance literature:

Multi-step reaction with 8 steps

1: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

2: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

3: imidazole / dimethylformamide / 3 h / 25 °C

4: 67 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

5: 82 percent / n-Bu₄NF / toluene; tetrahydrofuran / 0.08 h / 0 °C

6: 55 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

7: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -78 deg C, 50 min, 2.) THF, from -78 deg C to RT, 17.5 h

8: NaBH₄ / ethanol / 0.75 h

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; lithium perchlorate; caesium carbonate; triethylamine; diisopropylamine; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm960092w

upstream raw materials:

N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-{1-methyl-1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-ethyl}-benzamide

N-(2-chlorethyl)morpholine

4-Isopropylphenol

1-ethylcyclopentan-1-amine

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